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Z-Selective Olefin Metathesis Reactions

XiMo’s Mo-, W-catalysts offer novel chemical opportunities for the organic chemists affording stereochemistries that are not attainable with the so far more frequently used Ru-catalysts.  Several Mo and W based catalysts have extremely high Z-selectivity (up to 99%), which is a critical asset in various academic and industrial projects.

Often the actual Z-isomer is responsible exclusively for the biological activity (e.g. pheromones, or drug substances). Furthermore, Z-selective olefins can be further converted to products with the required stereochemistry.  

Z-selective Cross-Metathesis of Allylic Amides

Hoveyda, Schrock et al. Z-Selective Catalytic Olefin Cross-Metathesis Nature 2011, 471, 461.

Schrock, Hoveyda, et. al. Molybdenum‐Based Complexes with Two Aryloxides and a Pentafluoroimido Ligand: Catalysts for Efficient Z‐Selective Synthesis of a Macrocyclic Trisubstituted Alkene by Ring‐Closing Metathesis Angew. Chemie Int. Ed., 2013, 52(7), 1939-1943.

Olefin Metathesis Highlights

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Ximo Hungary Kft.