XiMo’s Mo-, W-catalysts offer novel chemical opportunities for the organic chemists affording stereochemistries that are not attainable with the so far more frequently used Ru-catalysts. Several Mo and W based catalysts have extremely high Z-selectivity (up to 99%), which is a critical asset in various academic and industrial projects.
Often the actual Z-isomer is responsible exclusively for the biological activity (e.g. pheromones, or drug substances). Furthermore, Z-selective olefins can be further converted to products with the required stereochemistry.
Z-selective Cross-Metathesis of Allylic Amides
Schrock, Hoveyda, et. al. Molybdenum‐Based Complexes with Two Aryloxides and a Pentafluoroimido Ligand: Catalysts for Efficient Z‐Selective Synthesis of a Macrocyclic Trisubstituted Alkene by Ring‐Closing Metathesis Angew. Chemie Int. Ed., 2013, 52(7), 1939-1943.