Catalytic RCM has played a prominent role in connection with the synthesis of macrocyclic alkenes, a structural motif found in an array of biologically active molecules. There is a high demand to develop catalysts that reliably deliver kinetic control of stereoselectivity in the formation of large-ring olefins.
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Efficient and Selective Formation of Macrocyclic Disubstituted Z Alkenes by Ring-Closing Metathesis (RCM) Reactions Catalyzed by Mo- or W-Based Monoaryloxide Pyrrolide (MAP) Complexes: Applications to Total Syntheses of Epilachnene, Yuzu Lactone, Ambrettolide, Epothilone C, and Nakadomarin A
(Wang et al. Chem. Eur. J. 2013, 19, 2726 – 2740)