Catalytic Ring-Closing Metathesis

02. May, 2017

Catalytic RCM has played a prominent role in connection with the synthesis of macrocyclic alkenes, a structural motif found in an array of biologically active molecules. There is a high demand to develop catalysts that reliably deliver kinetic control of stereoselectivity in the formation of large-ring olefins.

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Kinetically E-selective macrocyclic ring-closing metathesis

30. January, 2017

Macrocyclic organic molecules are central to discovery of new drugs but their preparation is often challenging because of the energy barrier required for bringing together and fusing the two ends of an acyclic precursor. Ring-closing metathesis (RCM) is a widely used catalytic process that has allowed access to countless biologically active macrocyclic organic molecules even on large scale (up to 200 kilograms).

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